Today we present 25 new placebo and nocebo research papers, comments and abstracts identified during January 2021. As usual, they are based on new PUBMED publication using the search terms „placebo“ and „nocebo“ and are hand-selected from more than 1095 new publications during the preceding month. Previously published monthly updates can be found in our archive. Todays selection as well as all previously identified papers will also go into our placebo research library that currently contains more than 4,500 relevant papers. If you would like to get access to the full database, please register for our newsletter and provide us with your email address and affiliation.
Afach, S., Evrenoglou, T., Oubaya, N., Le Cleach, L., & Sbidian, E. (2021).
Most randomized controlled trials for psoriasis used placebo comparators despite the availability of effective treatments. J Clin Epidemiol, 133, 72-79. doi:10.1016/j.jclinepi.2021.01.013
https://www.ncbi.nlm.nih.gov/pubmed/33482295
Berger, S. E., Branco, P., Vachon-Presseau, E., Abdullah, T. B., Cecchi, G., & Apkarian, A. V. (2021).
Quantitative language features identify placebo responders in chronic back pain. Pain. doi:10.1097/j.pain.0000000000002175
https://www.ncbi.nlm.nih.gov/pubmed/33433145
Case, L., Adler-Neal, A. L., Wells, R. E., & Zeidan, F. (2021).
The role of expectations and endogenous opioids in mindfulness-based relief of experimentally-induced acute pain. Psychosom Med. doi:10.1097/PSY.0000000000000908
https://www.ncbi.nlm.nih.gov/pubmed/33480666
De Smet, S., Nikolin, S., Moffa, A., Suen, P., Vanderhasselt, M. A., Brunoni, A. R., & Razza, L. B. (2021).
Determinants of sham response in tDCS depression trials: a systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry, 109, 110261. doi:10.1016/j.pnpbp.2021.110261
https://www.ncbi.nlm.nih.gov/pubmed/33497753
Feldhaus, M. H., Horing, B., Sprenger, C., & Buchel, C. (2021).
Association of nocebo hyperalgesia and basic somatosensory characteristics in a large cohort. Sci Rep, 11(1), 762. doi:10.1038/s41598-020-80386-y
https://www.ncbi.nlm.nih.gov/pubmed/33436821
Flowers, K. M., Patton, M. E., Hruschak, V. J., Fields, K. G., Schwartz, E., Zeballos, J., Kang, J. D., Edwards, R. R., Kaptchuk, T. J., & Schreiber, K. L. (2021).
Conditioned open-label placebo for opioid reduction following spine surgery: a randomized, controlled trial. Pain. doi:10.1097/j.pain.0000000000002185
https://www.ncbi.nlm.nih.gov/pubmed/33449503
Freed, B., Williams, B., Situ, X., Landsman, V., Kim, J., Moroz, A., Bang, H., & Park, J. J. (2021).
Blinding, sham, and treatment effects in randomized controlled trials for back pain in 2000-2019: A review and meta-analytic approach. Clin Trials, 1740774520984870. doi:10.1177/1740774520984870
https://www.ncbi.nlm.nih.gov/pubmed/33478258
Geers, A. L., Faasse, K., Guevarra, D. A., Clemens, K. S., Helfer, S. G., & Colagiuri, B. (2021).
Affect and emotions in placebo and nocebo effects: What do we know so far? Social and Personality Psychology Compass, 15(1), e12575. doi:https://doi.org/10.1111/spc3.12575
https://onlinelibrary.wiley.com/doi/abs/10.1111/spc3.12575
Gukasyan, N., & Nayak, S. M. (2021).
Psychedelics, placebo effects, and set and setting: Insights from common factors theory of psychotherapy. Transcult Psychiatry. doi:10.1177/1363461520983684
https://www.ncbi.nlm.nih.gov/pubmed/33499762
Ikemoto, T., Ueno, T., Arai, Y. C., Wakao, N., Hirasawa, A., Hayashi, K., & Deie, M. (2020).
Open-Label Placebo Trial among Japanese Patients with Chronic Low Back Pain. Pain Res Manag, 2020, 6636979. doi:10.1155/2020/6636979
https://www.ncbi.nlm.nih.gov/pubmed/33425079
Kaertner, L. S., Steinborn, M. B., Kettner, H., Spriggs, M. J., Roseman, L., Buchborn, T., Balaet, M., Timmermann, C., Erritzoe, D., & Carhart-Harris, R. L. (2021).
Positive expectations predict improved mental-health outcomes linked to psychedelic microdosing. Sci Rep, 11(1), 1941. doi:10.1038/s41598-021-81446-7
https://www.ncbi.nlm.nih.gov/pubmed/33479342
Kiltz, U., Pudelko, J. C., Tsiami, S., Baraliakos, X., & Braun, J. (2021).
Non-medical switching from reference to biosimilar etanercept – no evidence for nocebo effect: a retrospective analysis of real-life data. Clin Exp Rheumatol.
https://www.ncbi.nlm.nih.gov/pubmed/33427615
Kleine-Borgmann, J., Schmidt, K., Billinger, M., Forkmann, K., Wiech, K., & Bingel, U. (2021).
Effects of open-label placebos on test performance and psychological well-being in healthy medical students: a randomized controlled trial. Sci Rep, 11(1), 2130. doi:10.1038/s41598-021-81502-2
https://www.ncbi.nlm.nih.gov/pubmed/33483552
Lee, I. S., Jung, W. M., Lee, Y. S., Wallraven, C., & Chae, Y. (2021).
Operant and classical learning principles underlying mind-body interaction in pain modulation: a pilot fMRI study. Sci Rep, 11(1), 1663. doi:10.1038/s41598-021-81134-6
https://www.ncbi.nlm.nih.gov/pubmed/33462278
McLemore, B. H., McLemore, S. G., Rogers, R. R., Pederson, J. A., Williams, T. D., Marshall, M. R., & Ballmann, C. G. (2020).
Nocebo Effects on Perceived Muscle Soreness and Exercise Performance Following Unaccustomed Resistance Exercise: A Pilot Study. J Funct Morphol Kinesiol, 5(2). doi:10.3390/jfmk5020040
https://www.ncbi.nlm.nih.gov/pubmed/33467255
Olson, J. A., & Raz, A. (2021).
Applying insights from magic to improve deception in research: The Swiss cheese model. Journal of Experimental Social Psychology, 92, 104053. doi: 10.1016/j.jesp.2020.104053
https://www.sciencedirect.com/science/article/pii/S0022103120303930
Peerdeman, K. J., Geers, A. L., Della Porta, D., Veldhuijzen, D. S., & Kirsch, I. (2021).
Underpredicting pain: an experimental investigation into the benefits and risks. Pain. doi:10.1097/j.pain.0000000000002199
https://www.ncbi.nlm.nih.gov/pubmed/33470747
Perfitt, J. S., Plunkett, N., & Jones, S. (2020).
Placebo effect in the management of chronic pain. BJA Educ, 20(11), 382-387. doi:10.1016/j.bjae.2020.07.002
https://www.ncbi.nlm.nih.gov/pubmed/33456922
Petit, J., Antignac, M., Poilverd, R. M., Baratto, R., Darthout, S., Desouches, S., Louati, K., Deparis, N., Berenbaum, F., & Beauvais, C. (2021).
Multidisciplinary team intervention to reduce the nocebo effect when switching from the originator infliximab to a biosimilar. RMD Open, 7(1). doi:10.1136/rmdopen-2020-001396
https://www.ncbi.nlm.nih.gov/pubmed/33495387
Richardson, M., Kleinstauber, M., & Wong, D. (2020).
Nocebo-Hypothesis Cognitive Behavioral Therapy (NH-CBT) for Persons With Functional Neurological Symptoms (Motor Type): Design and Implementation of a Randomized Active-Controlled Trial. Front Neurol, 11, 586359. doi:10.3389/fneur.2020.586359
https://www.ncbi.nlm.nih.gov/pubmed/33424742
Rutgen, M., Wirth, E. M., Riecansky, I., Hummer, A., Windischberger, C., Petrovic, P., Silani, G., & Lamm, C. (2021).
Beyond Sharing Unpleasant Affect-Evidence for Pain-Specific Opioidergic Modulation of Empathy for Pain. Cereb Cortex. doi:10.1093/cercor/bhaa385
https://www.ncbi.nlm.nih.gov/pubmed/33454739
Schlintl, C., & Schienle, A. (2020).
Information About the Optimism of a Placebo/Nocebo Provider and Placebo/Nocebo Side Effects. Front Psychol, 11, 608595. doi:10.3389/fpsyg.2020.608595
https://www.ncbi.nlm.nih.gov/pubmed/33519617
Slomski, A. (2021).
“Important Conversations” Are Needed to Explain the Nocebo Effect. JAMA. doi:10.1001/jama.2020.25840
https://www.ncbi.nlm.nih.gov/pubmed/33533926
Yang, Z., Li, Y., Zou, Z., Zhao, Y., Zhang, W., Jiang, H., Hou, Y., Li, Y., & Zheng, Q. (2021).
Does patient’s expectation benefit acupuncture treatment?: A protocol for systematic review and meta-analysis. Medicine, 100(1), e24178. doi:10.1097/MD.0000000000024178
https://www.ncbi.nlm.nih.gov/pubmed/33429804
Zareba, R., Rysiak, E., Przylipiak, A., & Oscilowska, I. (2021).
Ethical – legal evaluation of the use of placebo in clinical trials. J Cosmet Dermatol. doi:10.1111/jocd.13967
https://www.ncbi.nlm.nih.gov/pubmed/33533184
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