Today we present 35 new placebo and nocebo research papers, comments and abstracts identified during March 2020. As usual, they are based on new PUBMED publication using the search terms „placebo“ and „nocebo“ and are hand-selected from more than 965 new publications during the preceding month. Previously published monthly updates can be found in our archive. Todays selection as well as all previously identified papers will also go into our placebo research library that currently contains more than 4,500 relevant papers. If you would like to get access to the full database, please register for our newsletter and provide us with your email address and affiliation.
Alves, M., Caldeira, D., Rato, M. L., Duarte, G. S., Ferreira, A. N., Ferro, J., & Ferreira, J. J. (2020).
Cardiovascular Adverse Events Reported in Placebo Arm of Randomized Controlled Trials in Parkinson’s Disease. J Parkinsons Dis. doi:10.3233/JPD-191907
https://www.ncbi.nlm.nih.gov/pubmed/32116264
Amanzio, M., Vase, L., & Mitsikostas, D. D. (2020).
Editorial: Nocebo Effects and Their Influence on Clinical Trials and Practice: Modulating Factors in Healthy and Pathological Conditions. Front Pharmacol, 11, 100. doi:10.3389/fphar.2020.00100
https://www.ncbi.nlm.nih.gov/pubmed/32140109
Braithwaite, F. A., Walters, J. L., Moseley, G. L., Williams, M. T., & McEvoy, M. P. (2020).
Towards more credible shams for physical interventions: A Delphi survey. Clin Trials, 1740774520910365. doi:10.1177/1740774520910365
https://www.ncbi.nlm.nih.gov/pubmed/32153205
Cantini, F., Niccoli, L., Franchi, G., Damiani, A., & Benucci, M. (2020).
The Nocebo Effect in Rheumatology: An Unexplored Issue. Isr Med Assoc J, 22(3), 185-190.
https://www.ncbi.nlm.nih.gov/pubmed/32147985
Chung, Y. C., Lewthwaite, R., Winstein, C. J., Monterosso, J. R., & Fisher, B. E. (2020).
Expectancy and affective response to challenging balance practice conditions in individuals with Parkinson’s disease. Eur J Neurosci. doi:10.1111/ejn.14723
https://www.ncbi.nlm.nih.gov/pubmed/32176392
Cousins, S., Blencowe, N. S., Tsang, C., Chalmers, K., Mardanpour, A., Carr, A. J., Campbell, M. K., Cook, J. A., Beard, D. J., & Blazeby, J. M. (2020).
Optimizing the design of invasive placebo interventions in randomized controlled trials. Br J Surg. doi:10.1002/bjs.11509
https://www.ncbi.nlm.nih.gov/pubmed/32187680
Czerniak, E., Oberlander, T. F., Weimer, K., Kossowsky, J., & Enck, P. (2020).
“Placebo by Proxy” and “Nocebo by Proxy” in Children: A Review of Parents’ Role in Treatment Outcomes. Front Psychiatry, 11, 169. doi:10.3389/fpsyt.2020.00169
https://www.ncbi.nlm.nih.gov/pubmed/32218746
Devlin, E. J., Whitford, H. S., Denson, L. A., & Potter, A. E. (2020).
‘Measuring up’: A comparison of two response expectancy assessment formats completed by men treated with radiotherapy for prostate cancer. J Psychosom Res, 132, 109979. doi:10.1016/j.jpsychores.2020.109979
https://www.ncbi.nlm.nih.gov/pubmed/32146249
Gelfand, S. (2020).
The Nocebo Effect and Informed Consent-Taking Autonomy Seriously. Camb Q Healthc Ethics, 29(2), 223-235. doi:10.1017/S0963180119001026
https://www.ncbi.nlm.nih.gov/pubmed/32159495
Gopalakrishnan, M., Zhu, H., Farchione, T. R., Mathis, M., Mehta, M., Uppoor, R., & Younis, I. (2020).
The Trend of Increasing Placebo Response and Decreasing Treatment Effect in Schizophrenia Trials Continues: An Update From the US Food and Drug Administration. J Clin Psychiatry, 81(2). doi:10.4088/JCP.19r12960
https://www.ncbi.nlm.nih.gov/pubmed/32141721
Ho, D. (2020).
Commentary: Harm, Truth, and the Nocebo Effect. Camb Q Healthc Ethics, 29(2), 236-245. doi:10.1017/S0963180119001038
https://www.ncbi.nlm.nih.gov/pubmed/32159482
Jilch, S., Sel, R., & Shariat, S. F. (2020).
Medical practice and placebo response: an inseparable bond? Wien Klin Wochenschr. doi:10.1007/s00508-020-01626-9
https://www.ncbi.nlm.nih.gov/pubmed/32211987
Keebler, D., Teng, E., Chia, J., Galanter, J., Peake, J., & Tuckwell, K. (2020).
Regional variations in adverse event reporting rates and ACR responses in placebo/standard-of-care arms of rheumatoid arthritis trials. Rheumatology. doi:10.1093/rheumatology/keaa043
https://www.ncbi.nlm.nih.gov/pubmed/32182362
La Touche, R., Fernandez Perez, J. J., Martinez Garcia, S., Cuenca-Martinez, F., Lopez-de-Uralde-Villanueva, I., & Suso-Marti, L. (2020).
Hypoalgesic Effects of Aerobic and Isometric Motor Imagery and Action Observation Exercises on Asymptomatic Participants: A Randomized Controlled Pilot Trial. Pain Med. doi:10.1093/pm/pnaa015
https://www.ncbi.nlm.nih.gov/pubmed/32142135
Langenberg, M. C. C., Dekkers, O. M., & Roestenberg, M. (2020).
Are placebo controls necessary in controlled human infection trials for vaccines? Lancet Infect Dis, 20(4), e69-e74. doi:10.1016/S1473-3099(20)30020-7
https://www.ncbi.nlm.nih.gov/pubmed/32142640
Lasa, J. S., Zubiaurre, I., Rausch, A., & Olivera, P. (2020).
Placebo Use in the Context of Inflammatory Bowel Disease Clinical Trials. Arq Gastroenterol. doi:10.1590/S0004-2803.202000000-15
https://www.ncbi.nlm.nih.gov/pubmed/32130303
Lorenzo-Luaces, L., Rodriguez-Quintana, N., Riley, T. N., & Weisz, J. R. (2020).
A placebo prognostic index (PI) as a moderator of outcomes in the treatment of adolescent depression: Could it inform risk-stratification in treatment with cognitive-behavioral therapy, fluoxetine, or their combination? Psychother Res, 1-14. doi:10.1080/10503307.2020.1747657
https://www.ncbi.nlm.nih.gov/pubmed/32223373
Meeuwis, S. H., van Middendorp, H., van Laarhoven, A. I. M., van Leijenhorst, C., Pacheco-Lopez, G., Lavrijsen, A. P. M., Veldhuijzen, D. S., & Evers, A. W. M. (2020).
Placebo and nocebo effects for itch and itch-related immune outcomes: a systematic review of animal and human studies. Neurosci Biobehav Rev. doi:10.1016/j.neubiorev.2020.03.025
https://www.ncbi.nlm.nih.gov/pubmed/32240668
Naharudin, M. N., Adams, J., Richardson, H., Thomson, T., Oxinou, C., Marshall, C., Clayton, D. J., Mears, S. A., Yusof, A., Hulston, C. J., & James, L. J. (2020).
Viscous placebo and carbohydrate breakfasts similarly decrease appetite and increase resistance exercise performance compared to a control breakfast in trained males. Br J Nutr, 1-25. doi:10.1017/S0007114520001002
https://www.ncbi.nlm.nih.gov/pubmed/32174286
Nordin, S. (2020).
Mechanisms underlying nontoxic indoor air health problems: A review. Int J Hyg Environ Health, 226, 113489. doi:10.1016/j.ijheh.2020.113489
https://www.ncbi.nlm.nih.gov/pubmed/32163882
Okusogu, C., Wang, Y., Akintola, T., Haycock, N. R., Raghuraman, N., Greenspan, J. D., Phillips, J., Dorsey, S. G., Campbell, C. M., & Colloca, L. (2020).
Placebo hypoalgesia: racial differences. Pain. doi:10.1097/j.pain.0000000000001876
https://www.ncbi.nlm.nih.gov/pubmed/32205528
Olson, J. A., Suissa-Rocheleau, L., Lifshitz, M., Raz, A., & Veissiere, S. P. L. (2020).
Tripping on nothing: placebo psychedelics and contextual factors. Psychopharmacology (Berl). doi:10.1007/s00213-020-05464-5
https://www.ncbi.nlm.nih.gov/pubmed/32144438
Previtali, D., Merli, G., Di Laura Frattura, G., Candrian, C., Zaffagnini, S., & Filardo, G. (2020).
The Long-Lasting Effects of “Placebo Injections” in Knee Osteoarthritis: A Meta-Analysis. Cartilage, 1947603520906597. doi:10.1177/1947603520906597
https://www.ncbi.nlm.nih.gov/pubmed/32186401
Romero, J., Larimer, P., Chang, B., Goldenholz, S. R., & Goldenholz, D. M. (2020).
Natural variability in seizure frequency: Implications for trials and placebo. Epilepsy Res, 162, 106306. doi:10.1016/j.eplepsyres.2020.106306
https://www.ncbi.nlm.nih.gov/pubmed/32172145
Sinyor, M., Cheung, C. P., Abraha, H. Y., Lanctot, K. L., Saleem, M., Liu, C. S., Li, A., Juda, A., Levitt, A. J., Cheung, A. H., & Schaffer, A. (2020).
Antidepressant-placebo differences for specific adverse events in major depressive disorder: A systematic review. J Affect Disord, 267, 185-190. doi:10.1016/j.jad.2020.02.013
https://www.ncbi.nlm.nih.gov/pubmed/32217218
Skvortsova, A., Veldhuijzen, D. S., de Rover, M., Pacheco-Lopez, G., Bakermans-Kranenburg, M., Van Jzendoorn M., Chavannes, N. H., van Middendorp, H., & Evers, A. W. M. (2020).
Effects of oxytocin administration and conditioned oxytocin on brain activity: An fMRI study. PLoS One, 15(3), e0229692. doi:10.1371/journal.pone.0229692
https://www.ncbi.nlm.nih.gov/pubmed/32191722
Stridh, A., Ponten, M., Arver, S., Kirsch, I., Abe, C., & Jensen, K. B. (2020).
Placebo Responses Among Men With Erectile Dysfunction Enrolled in Phosphodiesterase 5 Inhibitor Trials: A Systematic Review and Meta-analysis. JAMA Netw Open, 3(3), e201423. doi:10.1001/jamanetworkopen.2020.1423
https://www.ncbi.nlm.nih.gov/pubmed/32196105
The Lancet (2020).
Editorial. Gaining control: placebos in surgery trials. Lancet, 395(10226), 756. doi:10.1016/S0140-6736(20)30524-9
https://www.ncbi.nlm.nih.gov/pubmed/32145773
Thomaidou, M. A., Veldhuijzen, D. S., Peerdeman, K. J., Wiebing, N. Z. S., Blythe, J. S., & Evers, A. W. M. (2020).
Learning mechanisms in nocebo hyperalgesia: the role of conditioning and extinction processes. Pain. doi:10.1097/j.pain.0000000000001861
https://www.ncbi.nlm.nih.gov/pubmed/32149863
Vaduganathan, M., Jhund, P. S., Claggett, B. L., Packer, M., Widimsky, J., Seferovic, P., Rizkala, A., Lefkowitz, M., Shi, V., McMurray, J. J. V., & Solomon, S. D. (2020).
A putative placebo analysis of the effects of sacubitril/valsartan in heart failure across the full range of ejection fraction. Eur Heart J. doi:10.1093/eurheartj/ehaa184
https://www.ncbi.nlm.nih.gov/pubmed/32221596
Wai-Lan Yeung, V., Geers, A. L., & Colloca, L. (2020).
Merely Possessing a Placebo Analgesic Improves Analgesia Similar to Using the Placebo Analgesic. Ann Behav Med. doi:10.1093/abm/kaaa007
https://www.ncbi.nlm.nih.gov/pubmed/32227161
Wall, L., Hinwood, M., Lang, D., Smith, A., Bunzli, S., Clarke, P., Choong, P. F. M., Dowsey, M. M., & Paolucci, F. (2020).
Attitudes of patients and surgeons towards sham surgery trials: a protocol for a scoping review of attributes to inform a discrete choice experiment. BMJ Open, 10(3), e035870. doi:10.1136/bmjopen-2019-035870
https://www.ncbi.nlm.nih.gov/pubmed/32161162
Wang, Y., Tricou, C., Raghuraman, N., Akintola, T., Haycock, N. R., Blasini, M., Phillips, J., Zhu, S., & Colloca, L. (2020).
Modeling Learning Patterns to Predict Placebo Analgesic Effects in Healthy and Chronic Orofacial Pain Participants. Front Psychiatry, 11, 39. doi:10.3389/fpsyt.2020.00039
https://www.ncbi.nlm.nih.gov/pubmed/32116854
Wei, J. C., Zhang, L. J., & Huang, J. X. (2020).
Placebo responses in ankylosing spondylitis patients worldwide: variations and possible explanations. Expert Rev Clin Immunol, 1-4. doi:10.1080/1744666X.2020.1748500
https://www.ncbi.nlm.nih.gov/pubmed/32213079
Zhao, Y., Liu, R., Zhang, J., Luo, J., & Zhang, W. (2020).
Placebo Effect on Modulating Empathic Pain: Reduced Activation in Posterior Insula. Front Behav Neurosci, 14, 8. doi:10.3389/fnbeh.2020.00008
https://www.ncbi.nlm.nih.gov/pubmed/32116589