Today we present 39 new placebo and nocebo research papers, comments and abstracts identified during September 2019. As usual, they are based on new PUBMED publication using the search terms „placebo“ and „nocebo“ and are hand-selected from more than 890 new publications during the preceding month. Previously published monthly updates can be found in our archive. Todays selection as well as all previously identified papers will also go into our placebo research library that currently contains more than 4,000 relevant papers. If you would like to get access to the full database, please register for our newsletter and provide us with your email address and affiliation.
Altayar, O., Noureddin, N., Thanda Han, M. A., Murad, M. H., & Noureddin, M. (2019).
Fibrosis Changes in the Placebo Arm of NASH Clinical Trials. Clin Gastroenterol Hepatol, 17(11), 2387. doi:10.1016/j.cgh.2019.05.016
https://www.ncbi.nlm.nih.gov/pubmed/31543242
Amanzio, M., & Palermo, S. (2019).
Pain Anticipation and Nocebo-Related Responses: A Descriptive Mini-Review of Functional Neuroimaging Studies in Normal Subjects and Precious Hints on Pain Processing in the Context of Neurodegenerative Disorders. Front Pharmacol, 10, 969. doi:10.3389/fphar.2019.00969
https://www.ncbi.nlm.nih.gov/pubmed/31551779
Bernstein, M. H., Magill, M., Weiss, A. P., Kaptchuk, T. J., Blease, C., Kirsch, I., Rich, J. D., Becker, S. J., Mach, S., Beaudoin, F. L. (2019).
Are Conditioned Open Placebos Feasible as an Adjunctive Treatment to Opioids? Results from a Single-Group Dose-Extender Pilot Study with Acute Pain Patients. Psychother Psychosom, 1-3. doi:10.1159/000503038
https://www.ncbi.nlm.nih.gov/pubmed/31563914
Blease, C. R. (2019).
The role of placebos in family medicine: Implications of evidence and ethics for general practitioners. Aust J Gen Pract, 48(10), 700-705. doi:10.31128/AJGP-05-19-4939
https://www.ncbi.nlm.nih.gov/pubmed/31569323
Cai, L., & He, L. (2019).
Placebo effects and the molecular biological components involved. Gen Psychiatr, 32(5), e100089. doi:10.1136/gpsych-2019-100089
https://www.ncbi.nlm.nih.gov/pubmed/31552390
Colloca, L. (2019).
How do placebo effects and patient-clinician relationships influence behaviors and clinical outcomes? Pain Rep, 4(3), e758. doi:10.1097/PR9.0000000000000758
https://www.ncbi.nlm.nih.gov/pubmed/31583366
Ekblom, O. (2019).
Placebo “exercise drink” study provides a welcome wake-up call about the importance of rigorous research. Acta Paediatr. doi:10.1111/apa.15009
https://www.ncbi.nlm.nih.gov/pubmed/31577038
Fevang, P. (2019).
Doctors have a placebo effect. Tidsskr Nor Laegeforen, 139(12). doi:10.4045/tidsskr.19.03
https://www.ncbi.nlm.nih.gov/pubmed/31502801. 74
Finniss, D., Nicholas, M., Brooker, C., Cousins, M., & Benedetti, F. (2019).
Magnitude, response, and psychological determinants of placebo effects in chronic low-back pain: a randomised, double-blinded, controlled trial. Pain Rep, 4(3), e744. doi:10.1097/PR9.0000000000000744
https://www.ncbi.nlm.nih.gov/pubmed/31583358
Geers, A. L., Fowler, S. L., Helfer, S. G., & Murray, A. B. (2019).
A test of psychological and electrodermal changes immediately after the delivery of 3 analgesic treatment messages. Pain Rep, 4(3), e693. doi:10.1097/PR9.0000000000000693
https://www.ncbi.nlm.nih.gov/pubmed/31583337
Gklinos, P., Papadopoulos, D., & Mitsikostas, D. D. (2019).
Nocebo in multiple sclerosis trials: A meta-analysis on oral and newer injectable disease-modifying treatments. Mult Scler Relat Disord, 36, 101389. doi:10.1016/j.msard.2019.101389
https://www.ncbi.nlm.nih.gov/pubmed/31525626
Hall, K. T., & Loscalzo, J. (2019).
Drug-placebo additivity in randomized clinical trials. Clin Pharmacol Ther. doi:10.1002/cpt.1626
https://www.ncbi.nlm.nih.gov/pubmed/31502253
Hamberger, J., Meissner, K., Hinterberger, T., Loew, T., & Weimer, K. (2019).
Placebo Economics: A Systematic Review About the Economic Potential of Utilizing the Placebo Effect. Front Psychiatry, 10, 653. doi:10.3389/fpsyt.2019.00653
https://www.ncbi.nlm.nih.gov/pubmed/31572237
Heron, A., Leroux, C., & Dubayle, D. (2019).
[Use of placebo in French hospitals: data from polyvalent medicine units]. Med Sci (Paris), 35(8-9), 674-681. doi:10.1051/medsci/2019127
https://www.ncbi.nlm.nih.gov/pubmed/31532380
Hurst, P., Schipof-Godart, L., Hettinga, F., Roelands, B., & Beedie, C. (2019).
Improved 1000-m Running Performance and Pacing Strategy With Caffeine and Placebo: A Balanced Placebo Design Study. Int J Sports Physiol Perform, 1-6. doi:10.1123/ijspp.2019-0230
https://www.ncbi.nlm.nih.gov/pubmed/31575826
Janssens, T., Meulders, A., Cuyvers, B., Colloca, L., & Vlaeyen, J. W. S. (2019).
Placebo and nocebo effects and operant pain-related avoidance learning. Pain Rep, 4(3), e748. doi:10.1097/PR9.0000000000000748
https://www.ncbi.nlm.nih.gov/pubmed/31583361
Jonas, W. B. (2019).
The Myth of the Placebo Response. Front Psychiatry, 10, 577. doi:10.3389/fpsyt.2019.00577
https://www.ncbi.nlm.nih.gov/pubmed/31474888
Kirsch, I. (2017).
Response Expectancy and the Response to Antidepressant Medication. EBioMedicine, 25, 13. doi:10.1016/j.ebiom.2017.09.038
https://www.ncbi.nlm.nih.gov/pubmed/29037605
Kleine-Borgmann, J., Schmidt, K., Hellmann, A., & Bingel, U. (2019).
Effects of open-label placebo on pain, functional disability and spine mobility in chronic back pain patients: a randomized controlled trial. Pain. doi:10.1097/j.pain.0000000000001683
https://www.ncbi.nlm.nih.gov/pubmed/31479068
Lee, S. E., Lee, J. H., Kim, H. J., Lee, B. J., Cho, S. H., Price, D., Morice, A. H., Song, W. J. (2019).
Inhaled Corticosteroids and Placebo Treatment Effects in Adult Patients With Cough: A Systematic Review and Meta-analysis. Allergy Asthma Immunol Res, 11(6), 856-870. doi:10.4168/aair.2019.11.6.856
https://www.ncbi.nlm.nih.gov/pubmed/31552720
Li, F., Nasir, M., Olten, B., & Bloch, M. H. (2019).
Meta-Analysis of Placebo Response in Adult Antidepressant Trials. CNS Drugs. doi:10.1007/s40263-019-00662-y
https://www.ncbi.nlm.nih.gov/pubmed/31573058
Luckemann, L., Stangl, H., Straub, R. H., Schedlowski, M., & Hadamitzky, M. (2019).
Learned immunosuppressive placebo response attenuates disease progression in a rodent model of rheumatoid arthritis. Arthritis Rheumatol. doi:10.1002/art.41101
https://www.ncbi.nlm.nih.gov/pubmed/31509354
Manai, M., van Middendorp, H., Veldhuijzen, D. S., Huizinga, T. W. J., & Evers, A. W. M. (2019).
How to prevent, minimize, or extinguish nocebo effects in pain: a narrative review on mechanisms, predictors, and interventions. Pain Rep, 4(3), e699. doi:10.1097/PR9.0000000000000699
https://www.ncbi.nlm.nih.gov/pubmed/31583340
Matthiesen, S. T., Lunde, S. J., Wohlert Kjaer, S., Carlino, E., & Vase, L. (2019).
Placebo analgesia effects across central nervous system diseases: what do we know and where do we need to go? Pain Rep, 4(3), e717. doi:10.1097/PR9.0000000000000717
https://www.ncbi.nlm.nih.gov/pubmed/31583343
Meeuwis, S. H., van Middendorp, H., Pacheco-Lopez, G., Ninaber, M. K., Lavrijsen, A. P. M., van der Wee, N. J. A., Veldhuijzen, D. S., & Evers, A. W. M. (2019).
Antipruritic placebo effects by conditioning H1-antihistamine. Psychosom Med. doi:10.1097/PSY.0000000000000743
https://www.ncbi.nlm.nih.gov/pubmed/31490841
Okusogu, C., & Colloca, L. (2019).
Placebo hypoalgesia: above and beyond expectancy and conditioning. Curr Opin Behav Sci, 26, 75-81. doi:10.1016/j.cobeha.2018.10.008
https://www.ncbi.nlm.nih.gov/pubmed/31538101
Palese, A., Rossettini, G., Colloca, L., & Testa, M. (2019).
The impact of contextual factors on nursing outcomes and the role of placebo/nocebo effects: a discussion paper. Pain Rep, 4(3), e716. doi:10.1097/PR9.0000000000000716
https://www.ncbi.nlm.nih.gov/pubmed/31583342
Ponten, M., Ljotsson, B., & Jensen, K. (2019).
Shaping placebo analgesic responses on the Internet: a randomized experimental trial. Pain Rep, 4(3), e698. doi:10.1097/PR9.0000000000000698
https://www.ncbi.nlm.nih.gov/pubmed/31583339
Rubin, R. (2019).
Matters of the Mind: Honest Placebos, Hostility and Heart Attacks, and Sleepless Nights. JAMA. doi:10.1001/jama.2019.15983
https://www.ncbi.nlm.nih.gov/pubmed/31580412
Rushton, D. H., & Van Neste, D. J. (2019).
Lessons from the Past: Avoiding Placebo Generated Increased Hair Counts. Int J Trichology, 11(4), 144-146. doi:10.4103/ijt.ijt_37_19
https://www.ncbi.nlm.nih.gov/pubmed/31523104
Saunders, B., Saito, T., Klosterhoff, R., de Oliveira, L. F., Barreto, G., Perim, P., Pinto, A. J., Lima, F., de Sa Pinto, A. L., & Gualano, B. (2019).
“I put it in my head that the supplement would help me”: Open-placebo improves exercise performance in female cyclists. PLoS One, 14(9), e0222982. doi:10.1371/journal.pone.0222982
https://www.ncbi.nlm.nih.gov/pubmed/31550286
Schaefer, M., Denke, C., Harke, R., Olk, N., Erkovan, M., & Enge, S. (2019).
Open-label placebos reduce test anxiety and improve self-management skills: A randomized-controlled trial. Sci Rep, 9(1), 13317. doi:10.1038/s41598-019-49466-6
https://www.ncbi.nlm.nih.gov/pubmed/31527670
Sharma, T., Guski, L. S., Freund, N., Meng, D. M., & Gtzsche, P. C. (2019).
Drop-out rates in placebo-controlled trials of antidepressant drugs: A systematic review and meta-analysis based on clinical study reports. Int J Risk Saf Med. doi:10.3233/JRS-195041
https://www.ncbi.nlm.nih.gov/pubmed/31561390
Sobotka, L. A., & Levin, D. (2019).
Rates of and Factors Associated With Placebo Response in Trials of Pharmacotherapies for Nonalcoholic Steatohepatitis: Systemic Review and Meta-analysis. Clin Gastroenterol Hepatol, 17(11), 2386. doi:10.1016/j.cgh.2019.04.042
https://www.ncbi.nlm.nih.gov/pubmed/31543241
Verma, T. (2019).
Placebo in psychotherapy of childhood depression. Indian J Psychiatry, 61(5), 539-540. doi:10.4103/psychiatry.IndianJPsychiatry_561_18
https://www.ncbi.nlm.nih.gov/pubmed/31579178
Wang, R. S., Croteau-Chonka, D. C., Silverman, E. K., Loscalzo, J., Weiss, S. T., & Hall, K. T. (2019).
Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma. Clin Pharmacol Ther. doi:10.1002/cpt.1646
https://www.ncbi.nlm.nih.gov/pubmed/31557306
Webster, R. K., Howick, J., Hoffmann, T., Macdonald, H., Collins, G. S., Rees, J., Napadow, V., Madigan, C., Price, A., Lamb, S. E., Bishop, F. L., Bokelmann, K., Papanikitas, A., Roberts, N.L., & Evers, A. W. M. (2019).
Inadequate description of placebo and sham controls in a systematic review of recent trials. Eur J Clin Invest, e13169. doi:10.1111/eci.13169
https://www.ncbi.nlm.nih.gov/pubmed/31519047
Yeung, V., Sharpe, L., Geers, A., & Colagiuri, B. (2019).
Choice, Expectations, and the Placebo Effect for Sleep Difficulty. Ann Behav Med. doi:10.1093/abm/kaz030
https://www.ncbi.nlm.nih.gov/pubmed/31504091
Zeidan, F., Baumgartner, J. N., & Coghill, R. C. (2019).
The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer. Pain Rep, 4(4), e759. doi:10.1097/PR9.0000000000000759
https://www.ncbi.nlm.nih.gov/pubmed/31579851