Today we present 27 new placebo and nocebo research papers, comments and abstracts identified during December 2019. As usual, they are based on new PUBMED publication using the search terms „placebo“ and „nocebo“ and are hand-selected from more than 900 new publications during the preceding month. Previously published monthly updates can be found in our archive. Todays selection as well as all previously identified papers will also go into our placebo research library that currently contains more than 4,500 relevant papers. If you would like to get access to the full database, please register for our newsletter and provide us with your email address and affiliation.
Aichner, S., Haile, A., Hoffmann, V., Olliges, E., Tschop, M. H., & Meissner, K. (2019).
The Role of Tactile Stimulation for Expectation, Perceived Treatment Assignment and the Placebo Effect in an Experimental Nausea Paradigm. Front Neurosci, 13, 1212. doi:10.3389/fnins.2019.01212
https://www.ncbi.nlm.nih.gov/pubmed/31798402
Allen, A. (2019).
A Kantian defence of placebo deception. Monash Bioeth Rev, 37(3-4), 81-93. doi:10.1007/s40592-019-00102-z
https://www.ncbi.nlm.nih.gov/pubmed/31786802
Andreasen, T. H., Christensen, M. O., Halling, A. S., Egeberg, A., & Thyssen, J. P. (2019).
Placebo response in phase 2 and 3 trials of systemic and biologic therapies for atopic dermatitis – a systematic review and meta-analysis. J Eur Acad Dermatol Venereol. doi:10.1111/jdv.16163
https://www.ncbi.nlm.nih.gov/pubmed/31856331
Benda, N., & Haenisch, B. (2020).
Enrichment designs using placebo nonresponders. Pharm Stat. doi:10.1002/pst.1992
https://www.ncbi.nlm.nih.gov/pubmed/31899854
Braun, J., Tsiami, S., Buehring, B., Kiefer, D., Andreica, I., Baraliakos, X., & Kiltz, U. (2019).
[Biosimilars and the nocebo effect]. Z Rheumatol. doi:10.1007/s00393-019-00729-7
https://www.ncbi.nlm.nih.gov/pubmed/31802197
Colloca, L., Panaccione, R., & Murphy, T. K. (2019).
The Clinical Implications of Nocebo Effects for Biosimilar Therapy. Front Pharmacol, 10, 1372. doi:10.3389/fphar.2019.01372
https://www.ncbi.nlm.nih.gov/pubmed/31849647
D’Amico, F., Pouillon, L., Argollo, M., Hart, A., Fiorino, G., Vegni, E., Radice, S., Gilardi, D., Fazio, M., Leone, S., Bonovas, S., Magro, F., Danese, S., & Peyrin-Biroulet, L. (2019).
Multidisciplinary management of the nocebo effect in biosimilar-treated IBD patients: Results of a workshop from the NOCE-BIO consensus group. Dig Liver Dis. doi:10.1016/j.dld.2019.11.004
https://www.ncbi.nlm.nih.gov/pubmed/31812570
Eccles, R. (2019).
The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials. Lung. doi:10.1007/s00408-019-00305-5
https://www.ncbi.nlm.nih.gov/pubmed/31834478
Fanti-Oren, S., Birenbaum-Carmeli, D., Eliakim, A., Pantanowitz, M., & Nemet, D. (2019).
The placebo effect on aerobic fitness test results is preserved following a multidisciplinary intervention program for treating childhood obesity. Scand J Med Sci Sports. doi:10.1111/sms.13621
https://www.ncbi.nlm.nih.gov/pubmed/31876029
Faria, V., Han, P., Joshi, A., Enck, P., & Hummel, T. (2019).
Verbal suggestions of nicotine content modulate ventral tegmental neural activity during the presentation of a nicotine-free odor in cigarette smokers. Eur Neuropsychopharmacol. doi:10.1016/j.euroneuro.2019.11.007
https://www.ncbi.nlm.nih.gov/pubmed/31812330
Frew, J. W., Jiang, C. S., Singh, N., Grand, D., Navrazhina, K., Vaughan, R., & Krueger, J. G. (2019).
Clinical Response Rates, Placebo Response Rates and Significantly Associated Covariates Are Dependent Upon Choice of Outcome Measure in Hidradenitis Suppurativa: A Post-Hoc Analysis of PIONEER 1 and 2 Individual Patient Data. J Am Acad Dermatol. doi:10.1016/j.jaad.2019.12.044
https://www.ncbi.nlm.nih.gov/pubmed/31881294
Fusco, N., Bernard, F., Roelants, F., Watremez, C., Musellec, H., Laviolle, B., Beloeil, H., & Effect of Language and Confusion on Pain During Peripheral Intravenous Catheterization (KTHYPE) group. (2019).
Hypnosis and communication reduce pain and anxiety in peripheral intravenous cannulation: Effect of Language and Confusion on Pain During Peripheral Intravenous Catheterization (KTHYPE), a multicentre randomised trial. Br J Anaesth. doi:10.1016/j.bja.2019.11.020
https://www.ncbi.nlm.nih.gov/pubmed/31862159
Gill, J., & Prasad, V. (2019).
Testing for blinding in sham-controlled studies for procedural interventions: the third-party video method. CMAJ, 191(10), E272-E273. doi:10.1503/cmaj.181590
https://www.ncbi.nlm.nih.gov/pubmed/30858182
Jockenhofer, F., Knust, C., Benson, S., Schedlowski, M., & Dissemond, J. (2019).
Influence of placebo effects on quality of life and wound healing in patients with chronic venous leg ulcers. J Dtsch Dermatol Ges. doi:10.1111/ddg.13996
https://www.ncbi.nlm.nih.gov/pubmed/31814307
Kube, T., Rief, W., Vivell, M. B., Schafer, N. L., Vermillion, T., Korfer, K., & Glombiewski, J. A. (2020).
Deceptive and Nondeceptive Placebos to Reduce Pain: An Experimental Study in Healthy Individuals. Clin J Pain, 36(2), 68-79. doi:10.1097/AJP.0000000000000781
https://www.ncbi.nlm.nih.gov/pubmed/31899746
Lakshmanan, S., Shekar, C., Kinninger, A., Dahal, S., Onuegbu, A., Cai, A. N., Hamal, S., Birudaraju, D., Roy, S. K., Nelson, J. R., Budoff, M. J., & Bhatt, D. L. (2019).
Comparison of Mineral Oil and Non-Mineral Oil Placebo on Coronary Plaque Progression by Coronary Computed Tomography Angiography. Cardiovasc Res. doi:10.1093/cvr/cvz329
https://www.ncbi.nlm.nih.gov/pubmed/31825484
Liu, C., Huang, Y., Chen, L., & Yu, R. (2019).
Lack of Evidence for the Effect of Oxytocin on Placebo Analgesia and Nocebo Hyperalgesia. Psychother Psychosom, 1-3. doi:10.1159/000504967
https://www.ncbi.nlm.nih.gov/pubmed/31865357
Mattarozzi, K., Fino, E., Panni, V., Agostini, A., Morganti, A. G., & Russo, P. M. (2019).
The Role Of Effective Radiation Therapist-Patient Communication In Alleviating Treatment-Related Pain And Procedural Discomfort During Radiotherapy. Patient Prefer Adherence, 13, 1861-1865. doi:10.2147/PPA.S214375
https://www.ncbi.nlm.nih.gov/pubmed/31802855
May, S., Brown, S. P., Schmicker, R. H., Emerson, S. S., Nkwopara, E., & Ginsburg, A. S. (2019).
Non-inferiority designs comparing placebo to a proven therapy for childhood pneumonia in low-resource settings. Clin Trials, 1740774519888460. doi:10.1177/1740774519888460
https://www.ncbi.nlm.nih.gov/pubmed/31814441
Pulopulos, M. M., Baeken, C., & De Raedt, R. (2019).
Cortisol response to stress: The role of expectancy and anticipatory stress regulation. Horm Behav, 117, 104587. doi:10.1016/j.yhbeh.2019.104587
https://www.ncbi.nlm.nih.gov/pubmed/31639385
Raghuraman, N., Wang, Y., Schenk, L. A., Furman, A. J., Tricou, C., Seminowicz, D. A., & Colloca, L. (2019).
Neural and behavioral changes driven by observationally-induced hypoalgesia. Sci Rep, 9(1), 19760. doi:10.1038/s41598-019-56188-2
https://www.ncbi.nlm.nih.gov/pubmed/31874985
Schenk, L. A., & Colloca, L. (2019).
The neural processes of acquiring placebo effects through observation. Neuroimage, 116510. doi:10.1016/j.neuroimage.2019.116510
https://www.ncbi.nlm.nih.gov/pubmed/31899287
Schneider, T., Luethi, J., Mauermann, E., Bandschapp, O., & Ruppen, W. (2019).
Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Adult Males. Anesthesiology. doi:10.1097/ALN.0000000000003076
https://www.ncbi.nlm.nih.gov/pubmed/31809325
Sharma, A., Kumar, N., Bandello, F., Loewenstein, A., & Kuppermann, B. D. (2019).
Need of education on biosimilars amongst ophthalmologists: combating the nocebo effect. Eye (Lond). doi:10.1038/s41433-019-0722-6
https://www.ncbi.nlm.nih.gov/pubmed/31784703
Tan, K., Wells, C. I., Dinning, P., Bissett, I. P., & O’Grady, G. (2019).
Placebo Response Rates in Electrical Nerve Stimulation Trials for Fecal Incontinence and Constipation: A Systematic Review and Meta-Analysis. Neuromodulation. doi:10.1111/ner.13092
https://www.ncbi.nlm.nih.gov/pubmed/31889364
Targum, S. D., Cameron, B. R., Ferreira, L., & MacDonald, I. D. (2020).
Early score fluctuation and placebo response in a study of major depressive disorder. J Psychiatr Res, 121, 118-125. doi:10.1016/j.jpsychires.2019.11.014
https://www.ncbi.nlm.nih.gov/pubmed/31812110
Whitlock, M. E., Woodward, P. W., & Alexander, R. C. (2019).
Is High Placebo Response Really a Problem in Depression Trials? A Critical Re-analysis of Depression Studies. Innov Clin Neurosci, 16(7-08), 12-17.
https://www.ncbi.nlm.nih.gov/pubmed/31832258
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