Placebo Publications March 2021

Today we present 30 new placebo and nocebo research papers, comments and abstracts identified during March 2021. As usual, they are based on new PUBMED publication using the search terms „placebo“ and „nocebo“ and are hand-selected from more than 1154 new publications during the preceding month. Previously published monthly updates can be found in our archive. Todays selection as well as all previously identified papers will also go into our placebo research library that currently contains more than 4,500 relevant papers. If you would like to get access to the full database, please register for our newsletter and provide us with your email address and affiliation.

Amanzio, M., Cipriani, G. E., & Bartoli, A. M. (2021).
How do nocebo effects in placebo groups of randomized controlled trials provide a possible explicative framework for the COVID-19 pandemic? Expert Rev Clin Pharmacol, 1-6. doi:10.1080/17512433.2021.1900728

Annoni, M., Buergler, S., Stewart-Ferrer, S., & Blease, C. (2021).
Placebo Studies and Patient Care: Where Are the Nurses? Front Psychiatry, 12, 591913. doi:10.3389/fpsyt.2021.591913

Ashour, A. S. A., Ali, A. S., on behalf of all co-authors (2021).
Authors’ Response: Can a three-arm RCT with two active drugs have one placebo? Yes, the literature contains many. J Pediatr Adolesc Gynecol. doi:10.1016/j.jpag.2021.03.006

Bosman, M., Elsenbruch, S., Corsetti, M., Tack, J., Simren, M., Winkens, B., Boumans, T., Masclee, A., & Keszthelyi, D. (2021).
The placebo response rate in pharmacological trials in patients with irritable bowel syndrome: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. doi:10.1016/S2468-1253(21)00023-6

Bridgland, V. M. E., & Takarangi, M. K. T. (2021).
Danger! Negative memories ahead: the effect of warnings on reactions to and recall of negative memories. Memory, 29(3), 319-329. doi:10.1080/09658211.2021.1892147

Caplan, A. I. (2021).
Placebo Controls: Now??? Arch Immunol Ther Exp, 69(1), 9. doi:10.1007/s00005-021-00612-x

Colagiuri, B., Sharpe, L., Ambarchi, Z., Glozier, N., Bartlett, D., Costa, D. S. J., & Scott, A. (2021).
Open-label placebo for insomnia (OPIN): study protocol for a cohort multiple randomised controlled trial. BMJ Open, 11(2), e044045. doi:10.1136/bmjopen-2020-044045

Gaab, J., Locher, C., & Trachsel, M. (2021).
The Ethics of Placebo and Nocebo in Psychotherapy. In Oxford Handbook of Psychotherapy Ethics: Oxford University Press.

Gutierrez-Hellin, J., Ruiz-Moreno, C., Aguilar-Navarro, M., Munoz, A., Varillas-Delgado, D., Amaro-Gahete, F. J., Roberts, J. D., & Del Coso, J. (2021).
Placebo Effect of Caffeine on Substrate Oxidation during Exercise. Nutrients, 13(3). doi:10.3390/nu13030782

Huys, A. M. L., Beck, B., Haggard, P., Bhatia, K. P., & Edwards, M. J. (2021).
No increased suggestibility to placebo in functional neurological disorder. Eur J Neurol. doi:10.1111/ene.14816

Kube, T., Hofmann, V. E., Glombiewski, J. A., & Kirsch, I. (2021).
Providing open-label placebos remotely-A randomized controlled trial in allergic rhinitis. PLoS One, 16(3), e0248367. doi:10.1371/journal.pone.0248367

Liccardi, G., Calzetta, L., Milanese, M., Bilo, M. B., Liccardi, M. V., Baiardini, I., Gargano, D., Lo Schiavo, M., Madonna, F., Montera, M. C., Papa, A., Pedicini, A., Habetswallner, F., Giordano, A., & Rogliani, P. (2021).
Can placebo challenge test (inducing a “nocebo effect”) be a suitable model to assess stress-induced bronchial obstruction? Suggestions from the multidisciplinary Working Groups “Stress-Asthma” and “AAIITO Regione Campania”. Eur Ann Allergy Clin Immunol. doi:10.23822/EurAnnACI.1764-1489.192

Mao, A., Barnes, K., Sharpe, L., Geers, A. L., Helfer, S. G., Faasse, K., & Colagiuri, B. (2021).
Using Positive Attribute Framing to Attenuate Nocebo Side Effects: A Cybersickness Study. Ann Behav Med. doi:10.1093/abm/kaaa115

McNeill, A. M., Monk, R. L., Qureshi, A. W., Litchfield, D., & Heim, D. (2021).
The Effects of Placebo and Moderate Dose Alcohol on Attentional Bias, Inhibitory Control and Subjective Craving. Alcohol Alcohol. doi:10.1093/alcalc/agab011

Mol, P. B. W. (2021).
Can a three-arm RCT with two active drugs have one placebo? J Pediatr Adolesc Gynecol. doi:10.1016/j.jpag.2021.02.106

Mostafaei, H., Janisch, F., Mori, K., Quhal, F., Pradere, B., Hajebrahimi, S., Roehrborn, C. G., & Shariat, S. F. (2021).
Placebo Response in Patients with Oral Therapy for Overactive Bladder: A Systematic Review and Meta-analysis. Eur Urol Focus. doi:10.1016/j.euf.2021.02.005

Nelson, A. J., Pagidipati, N. J., & Granger, C. B. (2021).
The SAMSON trial: Using a Placebo to Improve Medication Tolerability. Eur Heart J Cardiovasc Pharmacother. doi:10.1093/ehjcvp/pvab017

Olson, J. A., Lifshitz, M., Raz, A., & Veissiere, S. P. L. (2021).
Super Placebos: A Feasibility Study Combining Contextual Factors to Promote Placebo Effects. Front Psychiatry, 12, 644825. doi:10.3389/fpsyt.2021.644825

Park, J. K., Ahn, S. H., Shin, K., Lee, Y. J., Song, Y. W., & Lee, E. B. (2021).
Predictors of a placebo response in patients with hand osteoarthritis: post-hoc analysis of two randomized controlled trials. BMC Musculoskelet Disord, 22(1), 244. doi:10.1186/s12891-021-04089-9

Pecina, M., Dombrovski, A. Y., Price, R., & Karim, H. T. (2021).
Understanding the Neurocomputational Mechanisms of Antidepressant Placebo Effects. J Psychiatr Brain Sci, 6. doi:10.20900/jpbs.20210001

Schienle, A., & Jurinec, N. (2021).
Combined Cognitive-Behavioral Therapy and Placebo Treatment for Patients with Depression: A Follow-Up Assessment. Psychol Res Behav Manag, 14, 233-238. doi:10.2147/PRBM.S294940

Shah, E. D. (2021).
Optimising clinical trial design to manage placebo response in randomised controlled trials of irritable bowel syndrome. Lancet Gastroenterol Hepatol. doi:10.1016/S2468-1253(21)00056-X

Smits, R. M., Veldhuijzen, D. S., Olde Hartman, T., Peerdeman, K. J., Van Vliet, L. M., Van Middendorp, H., Rippe, R. C. A., Wulffraat, N. M., & Evers, A. W. M. (2021).
Explaining placebo effects in an online survey study: Does ‘Pavlov’ ring a bell? PLoS One, 16(3), e0247103. doi:10.1371/journal.pone.0247103

Sung, Y. K., & Lee, Y. H. (2021).
Placebo and nocebo responses in randomized controlled trials of Janus kinase inhibitor monotherapy for rheumatoid arthritis: A meta-analysis. Z Rheumatol. doi:10.1007/s00393-021-00969-6

Trachsel, M., Tekin, S., Biller-Andorno, N., Gaab, J., & Sadler, J. (2021).
Why Ethics Matter in Psychotherapy. In Oxford Handbook of Psychotherapy Ethics: Oxford University Press.

Webster, R. K., Bishop, F., Collins, G. S., Evers, A. W. M., Hoffmann, T., Knottnerus, J. A., Lamb, S. E., Macdonald, H., Madigan, C., Napadow, V., Price, A., Rees, J. L., & Howick, J. (2021).
Measuring the success of blinding in placebo-controlled trials: Should we be so quick to dismiss it? J Clin Epidemiol. doi:10.1016/j.jclinepi.2021.02.022

Werner, C. P., Birkhaeuer, J., Locher, C., Gerger, H., Heimgartner, N., Colagiuri, B., & Gaab, J. (2021).
Price information influences the subjective experience of wine: A framed field experiment. Food Quality and Preference, 92, 104223. doi:10.1016/j.foodqual.2021.104223

Wilhelmus Strijkers, R. H., Schreijenberg, M., Gerger, H., Koes, B. W., & Chiarotto, A. (2021).
Effectiveness of placebo interventions for patients with non-specific low back pain: a systematic review. Pain. doi:10.1097/j.pain.0000000000002272

Wunram, H. L., Hamacher, S., Oberste, M., Neufang, S., Belke, L., Janicke, F., Graf, C., Schonau, E., Bender, S., & Fricke, O. (2021).
Influence of motivational placebo-related factors on the effects of exercise treatment in depressive adolescents. Eur Child Adolesc Psychiatry. doi:10.1007/s00787-021-01742-5

Zunhammer, M., Spisak, T., Wager, T. D., Bingel, U., & Placebo Imaging Consortium (2021).
Meta-analysis of neural systems underlying placebo analgesia from individual participant fMRI data. Nat Commun, 12(1), 1391. doi:10.1038/s41467-021-21179-3

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