Today we present 40 new placebo and nocebo research papers, comments and abstracts identified during May 2021. As usual, they are based on new PUBMED publication using the search terms „placebo“ and „nocebo“ and are hand-selected from more than 1333 new publications during the preceding month. Previously published monthly updates can be found in our archive. Todays selection as well as all previously identified papers will also go into our placebo research library that currently contains more than 4,500 relevant papers. If you would like to get access to the full database, please register for our newsletter and provide us with your email address and affiliation.
Aggensteiner, P. M. (2021).
Editorial: The Complexity of Neurofeedback and Control of Placebo Effects. J Am Acad Child Adolesc Psychiatry. doi:10.1016/j.jaac.2021.05.008
https://www.ncbi.nlm.nih.gov/pubmed/34048885
Amanzio, M., Cipriani, G. E., & Bartoli, M. (2021).
How do nocebo effects in placebo groups of randomized controlled trials provide a possible explicative framework for the COVID-19 pandemic? Expert Rev Clin Pharmacol, 14(4), 439-444. doi:10.1080/17512433.2021.1900728
https://www.ncbi.nlm.nih.gov/pubmed/33682603
Andrade, C. (2021).
Active Placebo, the Parachute Meta-Analysis, the Nobel Prize, and the Efficacy of Electroconvulsive Therapy. J Clin Psychiatry, 82(2). doi:10.4088/JCP.21f13992
https://www.ncbi.nlm.nih.gov/pubmed/34000105
Barnes, K., Rottman, B. M., & Colagiuri, B. (2021).
The placebo effect: To explore or to exploit? Cognition, 214, 104753. doi:10.1016/j.cognition.2021.104753
https://www.ncbi.nlm.nih.gov/pubmed/34023671
Bartlett, J., Upshaw, W. N., & Obregon, D. (2021).
Interactions of the Placebo Effect and Transcranial Magnetic Stimulation. Prim Care Companion CNS Disord, 23(2). doi:10.4088/PCC.20lr02874
https://www.ncbi.nlm.nih.gov/pubmed/34000176
Bernstein, M. H., Fuchs, N., Rosenfield, M., Weiss, A. P., Blease, C., Locher, C., Magill, M., Rich, J., & Beaudoin, F. (2021).
Treating pain with open-label placebos: A qualitative study with post-surgical pain patients. J Pain. doi:10.1016/j.jpain.2021.05.001
https://www.ncbi.nlm.nih.gov/pubmed/34004348
Chen, C., Jonsson, S., Yang, S., Plan, E. L., & Karlsson, M. O. (2021).
Detecting placebo and drug effects on Parkinson’s disease symptoms by longitudinal item-score models. CPT Pharmacometrics Syst Pharmacol, 10(4), 309-317. doi:10.1002/psp4.12601
https://www.ncbi.nlm.nih.gov/pubmed/33951753
Colagiuri, B., Sharpe, L., Ambarchi, Z., Glozier, N., Bartlett, D., Costa, D. S. J., & Scott, A. (2021).
Open-label placebo for insomnia (OPIN): study protocol for a cohort multiple randomised controlled trial. BMJ Open, 11(2), e044045. doi:10.1136/bmjopen-2020-044045
https://www.ncbi.nlm.nih.gov/pubmed/33637548
Coleshill, M. J., Sharpe, L., & Colagiuri, B. (2021).
No evidence that attentional bias towards pain-related words is associated with verbally induced nocebo hyperalgesia: a dot-probe study. Pain Rep, 6(1), e921. doi:10.1097/PR9.0000000000000921
https://www.ncbi.nlm.nih.gov/pubmed/33981937
Daniali, H., & Flaten, M. A. (2021).
Experiencing COVID-19 symptoms without the disease: The role of nocebo in reporting of symptoms. Scand J Public Health, 14034948211018385. doi:10.1177/14034948211018385
https://www.ncbi.nlm.nih.gov/pubmed/34041973
De Jaeghere, E. A., Bouche, G., Hoebeke, P., Holbrouck, P. M., & Denys, H. G. (2020).
The nocebo effect and tobacco control – First, do no harm? Med Hypotheses, 139, 109615. doi:10.1016/j.mehy.2020.109615
https://www.ncbi.nlm.nih.gov/pubmed/32078961
De Pascalis, V., Scacchia, P., & Vecchio, A. (2021).
Influences of hypnotic suggestibility, contextual factors, and EEG alpha on placebo analgesia. Am J Clin Hypn, 63(4), 302-328. doi:10.1080/00029157.2020.1863182
https://www.ncbi.nlm.nih.gov/pubmed/33999775
Delang, N., Irwin, C., Cox, G. R., McCartney, D., & Desbrow, B. (2021).
Belief in caffeine’s ergogenic effect on cognitive function and endurance performance: A sham dose-response study. Hum Psychopharmacol, e2792. doi:10.1002/hup.2792
https://www.ncbi.nlm.nih.gov/pubmed/33939237
Fanti-Oren, S., Birenbaum-Carmeli, D., Eliakim, A., Pantanowitz, M., Schujovitzky, D., & Nemet, D. (2021).
The Effect of Information Placebo on Physical Activity in Overweight and Obese Children. Pediatr Exerc Sci, 1-5. doi:10.1123/pes.2020-0062
https://www.ncbi.nlm.nih.gov/pubmed/33958501
Faraone, S. V., Newcorn, J. H., Cipriani, A., Brandeis, D., Kaiser, A., Hohmann, S., Haege, A., & Cortese, S. (2021).
Placebo and nocebo responses in randomised, controlled trials of medications for ADHD: a systematic review and meta-analysis. Mol Psychiatry. doi:10.1038/s41380-021-01134-w
https://www.ncbi.nlm.nih.gov/pubmed/33972692
He, J., Perez, D. G., Le-Rademacher, J. L., Dodge, A., Enck, P., Loprinzi, C. L., & Zahrieh, D. (2021).
Does the placebo effect on hot flashes depend on the placebo dose? Support Care Cancer. doi:10.1007/s00520-021-06244-3
https://www.ncbi.nlm.nih.gov/pubmed/33973082
Hu, W., & Yang, J. (2021).
Reward anticipation buffers neuroendocrine and cardiovascular responses to acute psychosocial stress in healthy young adults. Stress, 1-9. doi:10.1080/10253890.2021.1923690
https://www.ncbi.nlm.nih.gov/pubmed/33970772
Jones, B. D. M., Weissman, C. R., Razza, L. B., Husain, M. I., Brunoni, A. R., & Daskalakis, Z. J. (2021).
Protocol for a systematic review and meta-analysis of the placebo response in treatment-resistant depression: comparison of multiple treatment modalities. BMJ Open, 11(2), e041349. doi:10.1136/bmjopen-2020-041349
https://www.ncbi.nlm.nih.gov/pubmed/33593773
Juul, S., Siddiqui, F., Barbateskovic, M., Jorgensen, C. K., Hengartner, M. P., Kirsch, I., Gluud, C., & Jakobsen, J. C. (2021).
Beneficial and harmful effects of antidepressants versus placebo, ‘active placebo’, or no intervention for adults with major depressive disorder: a protocol for a systematic review of published and unpublished data with meta-analyses and trial sequential analyses. Syst Rev, 10(1), 154. doi:10.1186/s13643-021-01705-6
https://www.ncbi.nlm.nih.gov/pubmed/34034811
Kirkwood, M. W., Howell, D. R., Brooks, B. L., Wilson, J. C., & Meehan Iii, W. P. (2021).
The Nocebo Effect and Pediatric Concussion. J Sport Rehabil, 1-7. doi:10.1123/jsr.2020-0519
https://www.ncbi.nlm.nih.gov/pubmed/34050035
Koenen, L. R., Pawlik, R. J., Icenhour, A., Petrakova, L., Forkmann, K., Theysohn, N., Engler, H., & Elsenbruch, S. (2021).
Associative learning and extinction of conditioned threat predictors across sensory modalities. Commun Biol, 4(1), 553. doi:10.1038/s42003-021-02008-1
https://www.ncbi.nlm.nih.gov/pubmed/33976383
Lee, Y. H., & Song, G. G. (2021).
Nocebo effects of Janus kinase inhibitors in the treatment of active ankylosing spondylitis. Int J Clin Pharmacol Ther. doi:10.5414/CP203956
https://pubmed.ncbi.nlm.nih.gov/34042579/
Leibowitz, K. A., Howe, L. C., & Crum, A. J. (2021).
Changing mindsets about side effects. BMJ open, 11(2), e040134. doi: 10.1136/bmjopen-2020-040134
https://pubmed.ncbi.nlm.nih.gov/33526496/
Lembo, A. J. (2020).
Understanding the Placebo and Nocebo Effects in Patients With Irritable Bowel Syndrome. Gastroenterol Hepatol (N Y), 16(7), 374-376.
https://www.ncbi.nlm.nih.gov/pubmed/34035744
Liu, T. Placebo Effects: A New Theory. Clinical Psychological Science, 0(0), 21677026211009799. doi:10.1177/21677026211009799
https://journals.sagepub.com/doi/abs/10.1177/21677026211009799
Malhi, G. S., & Bell, E. (2021).
Is the response to rTMS largely the result of non-specific effects? Aust N Z J Psychiatry, 55(5), 445-450. doi:10.1177/00048674211016043
https://www.ncbi.nlm.nih.gov/pubmed/33985353
Muthukumaraswamy, S., Forsyth, A., & Lumley, T. (2021).
Blinding and expectancy confounds in psychedelic randomised controlled trials. Expert Rev Clin Pharmacol. doi:10.1080/17512433.2021.1933434
https://www.ncbi.nlm.nih.gov/pubmed/34038314
Nestoriuc, Y., Pan, Y., Kinitz, T., Weik, E., & Shedden-Mora, M. C. (2021).
Informing About the Nocebo Effect Affects Patients’ Need for Information About Antidepressants – An Experimental Online Study. Front Psychiatry, 12, 587122. doi:10.3389/fpsyt.2021.587122
https://www.ncbi.nlm.nih.gov/pubmed/33986697
Pagnini, F., Volpato, E., Dell’Orto, S., Cavalera, C., Spina, M., & Banfi, P. (2021).
Illness Expectations Assessment in People with Asthma: A Tool for Explicit and Implicit Beliefs. J Asthma Allergy, 14, 449-455. doi:10.2147/JAA.S307763
https://www.ncbi.nlm.nih.gov/pubmed/33976554
Park, J. K., Ahn, S. H., Shin, K., Lee, Y. J., Song, Y. W., & Lee, E. B. (2021).
Predictors of a placebo response in patients with hand osteoarthritis: post-hoc analysis of two randomized controlled trials. BMC Musculoskelet Disord, 22(1), 244. doi:10.1186/s12891-021-04089-9
https://www.ncbi.nlm.nih.gov/pubmed/33663463
Schienle, A., Gremsl, A., & Wabnegger, A. (2021).
Placebo Effects in the Context of Religious Beliefs and Practices: A Resting-State Functional Connectivity Study. Front Behav Neurosci, 15, 653359. doi:10.3389/fnbeh.2021.653359
https://www.ncbi.nlm.nih.gov/pubmed/34025370
Sretavan Wong, K., Migo, M., Dougherty, D. D., & Ghaemi, S. N. (2021).
Neural correlates of citalopram and placebo response in acute bipolar depression: A randomized trial. J Psychiatr Res, 138, 463-466. doi:10.1016/j.jpsychires.2021.04.035
https://www.ncbi.nlm.nih.gov/pubmed/33965734
Thomaidou, M. A., Blythe, J. S., Houtman, S. J., Veldhuijzen, D. S., van Laarhoven, A. I. M., & Evers, A. W. M. (2021).
Temporal structure of brain oscillations predicts learned nocebo responses to pain. Sci Rep, 11(1), 9807. doi:10.1038/s41598-021-89368-0
https://www.ncbi.nlm.nih.gov/pubmed/33963251
Thomaidou, M. A., Veldhuijzen, D. S., Meulders, A., & Evers, A. W. M. (2021).
An experimental investigation into the mediating role of pain-related fear in boosting nocebo hyperalgesia. Pain, 162(1), 287-299. doi:10.1097/j.pain.0000000000002017
https://www.ncbi.nlm.nih.gov/pubmed/32910630
Thomaidou, M. A., Veldhuijzen, D. S., Peerdeman, K. J., Wiebing, N. Z. S., Blythe, J. S., & Evers, A. W. M. (2020).
Learning mechanisms in nocebo hyperalgesia: the role of conditioning and extinction processes. Pain, 161(7), 1597-1608. doi:10.1097/j.pain.0000000000001861
https://www.ncbi.nlm.nih.gov/pubmed/32149863
Tu, Y., Wilson, G., Camprodon, J., Dougherty, D. D., Vangel, M., Benedetti, F., Kaptchuk, T. J., Gollub, R. L., & Kong, J. (2021).
Manipulating placebo analgesia and nocebo hyperalgesia by changing brain excitability. Proc Natl Acad Sci U S A, 118(19). doi:10.1073/pnas.2101273118
https://www.ncbi.nlm.nih.gov/pubmed/33941677
Tugwell, P., & Tovey, D. (2021).
In 2021 When Is It Unethical to Use a Placebo in a Clinical Trial? J Clin Epidemiol, 133, A5-A6. doi:10.1016/j.jclinepi.2021.03.023
https://www.ncbi.nlm.nih.gov/pubmed/34024414
van Lennep, J. P. A., Trossel, F., Perez, R., Otten, R. H. J., van Middendorp, H., Evers, A. W. M., & Szadek, K. M. (2021).
Placebo effects in low back pain; a systematic review and meta-analysis of the literature. Eur J Pain. doi:10.1002/ejp.181
https://www.ncbi.nlm.nih.gov/pubmed/34051018
van Middendorp, H., Berende, A., Vos, F. J., Ter Hofstede, H. H. M., Kullberg, B. J., & Evers, A. W. M. (2021).
Expectancies as predictors of symptom improvement after antimicrobial therapy for persistent symptoms attributed to Lyme disease. Clin Rheumatol. doi:10.1007/s10067-021-05760-1
https://www.ncbi.nlm.nih.gov/pubmed/34031759
Weise, A., Luhnen, J., Buhn, S., Steffen, F., Zacher, S., Lauberger, J., Ates, D. M., Böhmer, A., Rosenau, H., Steckelberg, A., & Mathes, T. (2021).
Development, piloting, and evaluation of an evidence-based informed consent form for total knee arthroplasty (EvAb-Pilot): a protocol for a mixed methods study. Pilot Feasibility Stud, 7(1), 107. doi:10.1186/s40814-021-00843-x
https://www.ncbi.nlm.nih.gov/pubmed/33985574