Today we present 29 new placebo and nocebo research papers, comments and abstracts identified during Septermber 2021. As usual, they are based on new PUBMED publication using the search terms „placebo“ and „nocebo“ and are hand-selected from more than 825 new publications during the preceding month. Previously published monthly updates can be found in our archive. Todays selection as well as all previously identified papers will also go into our placebo research library that currently contains nearly 5,000 relevant papers. If you would like to get access to the full database, please register for our newsletter and provide us with your email address and affiliation.
Asan, L., Benson, S., & Bingel, U. (2021).
[Primum nil nocere: The nocebo effect in clinical practice]. MMW Fortschr Med, 163(15), 56-61. doi:10.1007/s15006-021-0173-4
https://www.ncbi.nlm.nih.gov/pubmed/34478093
Aslaksen, P. M. (2021).
Cutoff criteria for the placebo response: a cluster and machine learning analysis of placebo analgesia. Sci Rep, 11(1), 19205. doi:10.1038/s41598-021-98874-0
https://www.ncbi.nlm.nih.gov/pubmed/34584181
Atlas, L. Y. (2021).
A social affective neuroscience lens on placebo analgesia. Trends Cogn Sci. doi:10.1016/j.tics.2021.07.016
https://www.ncbi.nlm.nih.gov/pubmed/34538720
Barth, J., Muff, S., Kern, A., Zieger, A., Keiser, S., Zoller, M., Rosemann, T., Brinkhaus, B., Held, L., & Witt, C. M. (2021).
Effect of Briefing on Acupuncture Treatment Outcome Expectations, Pain, and Adverse Side Effects Among Patients With Chronic Low Back Pain: A Randomized Clinical Trial. JAMA Netw Open, 4(9), e2121418. doi:10.1001/jamanetworkopen.2021.21418
https://www.ncbi.nlm.nih.gov/pubmed/34505889
Beard, D. J., Campbell, M. K., Blazeby, J. M., Carr, A. J., Weijer, C., Cuthbertson, B. H., Buchbinder, R., Pinkney, T., Bishop, F. L., Pugh, J., Cousins, S., Harris, I., Lohmander, L. S., Blencowe, N., Gillies, K., Probst, P., Brennan, C., Cook, A., Farrar-Hockley, D., Savulescu, J., Huxtable, R., Rangan, A., Tracey, I., Brocklehurst, P., Ferreira, M. L., Nicholl, J., Reeves, B. C., Hamdy, F., Rowley, S. C., Lee, N., & Cook, J. A. (2021).
Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop. Health Technol Assess, 25(53), 1-52. doi:10.3310/hta25530
https://www.ncbi.nlm.nih.gov/pubmed/34505829
Borner, N., Weniger, M., Nossek, J., Kuonath, A., Schoenberg, M., Bosch, F., Angele, M., Frey, D., Werner, J., & Guba, M. (2021).
Patient expectations shape convalescence after major liver surgery – A prospective, randomized study. Int J Surg, 94, 106128. doi:10.1016/j.ijsu.2021.106128
https://www.ncbi.nlm.nih.gov/pubmed/34571263
Braithwaite, F. A., Walters, J. L., Moseley, G. L., Williams, M. T., & McEvoy, M. P. (2021).
A novel blinding protocol to test participant and therapist blinding during dry needling: a randomised controlled experiment. Physiotherapy. doi:10.1016/j.physio.2021.08.007
https://www.ncbi.nlm.nih.gov/pubmed/34579950
Colloca, L., Thomas, S., Yin, M., Haycock, N. R., & Wang, Y. (2021).
Pain experience and mood disorders during the lockdown of the COVID-19 pandemic in the United States: an opportunistic study. Pain Rep, 6(3), e958. doi:10.1097/PR9.0000000000000958
https://www.ncbi.nlm.nih.gov/pubmed/34589641
Cusin, C., & Colloca, L. (2021).
Treatment-Resistant Depression-Resistant to Placebos as Well? JAMA Netw Open, 4(9), e2127952. doi:10.1001/jamanetworkopen.2021.27952
https://www.ncbi.nlm.nih.gov/pubmed/34559235
Howard, J. P., Wood, F. A., Finegold, J. A., Nowbar, A. N., Thompson, D. M., Arnold, A. D., Rajkumar, C. A., Connolly, S., Cegla, J., Stride, C., Sever, P., Norton, C., Thom, S. A. M., Shun-Shin, M. J., & Francis, D. P. (2021).
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment. J Am Coll Cardiol, 78(12), 1210-1222. doi:10.1016/j.jacc.2021.07.022
https://www.ncbi.nlm.nih.gov/pubmed/34531021
Iolascon, G., & Moretti, A. (2021).
Myths and Truths about Placebo Effect in Rehabilitation for Musculoskeletal Pain. Adv Ther, 38(10), 4995-5001. doi:10.1007/s12325-021-01894-5
https://www.ncbi.nlm.nih.gov/pubmed/34476754
Jones, B. D. M., Razza, L. B., Weissman, C. R., Karbi, J., Vine, T., Mulsant, L. S., Blumberger, D. M., & Daskalakis, Z. J. (2021).
Magnitude of the Placebo Response Across Treatment Modalities Used for Treatment-Resistant Depression in Adults: A Systematic Review and Meta-analysis. JAMA Netw Open, 4(9), e2125531. doi:10.1001/jamanetworkopen.2021.25531
https://www.ncbi.nlm.nih.gov/pubmed/34559231
Kalokairinou, L., Specker Sullivan, L., & Wexler, A. (2021).
Neurofeedback as placebo: a case of unintentional deception? J Med Ethics. doi:10.1136/medethics-2021-107435
https://www.ncbi.nlm.nih.gov/pubmed/34521768
Leganes-Fonteneau, M., Bates, M. E., Islam, S., & Buckman, J. F. (2021).
Changes in interoception after alcohol administration correlate with expectancies and subjective effects. Addict Biol, e13098. doi:10.1111/adb.13098
https://www.ncbi.nlm.nih.gov/pubmed/34514670
Maher, C. G., Traeger, A. C., Abdel Shaheed, C., & O’Keeffe, M. (2021).
Placebos in clinical care: a suggestion beyond the evidence. Med J Aust. doi:10.5694/mja2.51230
https://www.ncbi.nlm.nih.gov/pubmed/34537963
Nann, S. (2021).
How beliefs in traditional healers impact on the use of allopathic medicine: In the case of indigenous snakebite in Eswatini. PLoS Negl Trop Dis, 15(9), e0009731. doi:10.1371/journal.pntd.0009731
https://www.ncbi.nlm.nih.gov/pubmed/34499648
Nasir, M., Li, F., Courley, S., Olten, B., & Bloch, M. H. (2021).
Meta-Analysis: Pediatric Placebo Response in Depression Trials Does Not Replicate in Anxiety and Obsessive-Compulsive Disorder Trials. J Child Adolesc Psychopharmacol. doi:10.1089/cap.2021.0030
https://www.ncbi.nlm.nih.gov/pubmed/34558984
Nayernouri, T. (2021).
The Expectant Brain and the Placebo Magic; Does it have a Survival Value? Arch Iran Med, 24(7), 585-590. doi:10.34172/aim.2021.83
https://www.ncbi.nlm.nih.gov/pubmed/34488325
Paumgartten, F. J. R. (2021).
Equipoise, placebo in clinical trials and Brazilian Code of Medical Ethics. Rev Assoc Med Bras (1992), 67(4), 490-495. doi:10.1590/1806-9282.20200929
https://www.ncbi.nlm.nih.gov/pubmed/34495049
Rakita, L., Goy, H., & Singh, G. (2021).
Descriptions of Hearing Aids Influence the Experience of Listening to Hearing Aids. Ear Hear. doi:10.1097/AUD.0000000000001130
https://www.ncbi.nlm.nih.gov/pubmed/34582394
Ruschil, V., Mazurak, N., Hofmann, M., Loskutova, E., Enck, P., Freilinger, T., & Weimer, K. (2021).
Decreased Autonomic Reactivity and Psychiatric Comorbidities in Neurological Patients With Medically Unexplained Sensory Symptoms: A Case-Control Study. Front Neurol, 12, 713391. doi:10.3389/fneur.2021.713391
https://www.ncbi.nlm.nih.gov/pubmed/34557148
Samartin-Veiga, N., Pidal-Miranda, M., Gonzalez-Villar, A. J., Bradley, C., Garcia-Larrea, L., O’Brien, A. T., & Carrillo-de-la-Pena, M. T. (2021).
Transcranial direct current stimulation of three cortical targets is no more effective than placebo as treatment for fibromyalgia: a double-blind sham-controlled clinical trial. Pain. doi:10.1097/j.pain.0000000000002493
https://www.ncbi.nlm.nih.gov/pubmed/34561393
Schaefer, M., Kuhnel, A., & Enge, S. (2021).
Comment on Evers et al. “What Should Clinicians Tell Patients about Placebo and Nocebo Effects?”: Open-Label Placebos May Reduce Feelings of Hunger during Weight Loss. Psychother Psychosom, 1-2. doi:10.1159/000518803
https://www.ncbi.nlm.nih.gov/pubmed/34515208
Shi, Y., Cui, S., Zeng, Y., Huang, S., Cai, G., Yang, J., & Wu, W. (2021).
Brain Network to Placebo and Nocebo Responses in Acute Experimental Lower Back Pain: A Multivariate Granger Causality Analysis of fMRI Data. Front Behav Neurosci, 15, 696577. doi:10.3389/fnbeh.2021.696577
https://www.ncbi.nlm.nih.gov/pubmed/34566591
Shi, Y., Zhan, H., Zeng, Y., Huang, S., Cai, G., Yang, J., & Wu, W. (2021).
Sex Differences in the Blood Oxygen Level-Dependent Signal to Placebo Analgesia and Nocebo Hyperalgesia in Experimental Pain: A Functional MRI Study. Front Behav Neurosci, 15, 657517. doi:10.3389/fnbeh.2021.657517
https://www.ncbi.nlm.nih.gov/pubmed/34497495
Torregrossa, M. M. (2021).
Failure of Losartan in a Clinical Trial for Posttraumatic Stress Disorder: Lack of Efficacy or Spotlight on the Power of Placebo? Biol Psychiatry, 90(7), 432-433. doi:10.1016/j.biopsych.2021.07.009
https://www.ncbi.nlm.nih.gov/pubmed/34503672
Toth, P. P. (2021).
That Myalgia of Yours Is Not From Statin Intolerance. J Am Coll Cardiol, 78(12), 1223-1226. doi:10.1016/j.jacc.2021.07.025
https://www.ncbi.nlm.nih.gov/pubmed/34531022
Vecchio, A., & De Pascalis, V. (2021).
ERP Indicators of Self-Pain and Other Pain Reductions due to Placebo Analgesia Responding: The Moderating Role of the Fight-Flight-Freeze System. Brain Sci, 11(9). doi:10.3390/brainsci11091192
https://www.ncbi.nlm.nih.gov/pubmed/34573212
Watrin, L., Nordin, S., Szemerszky, R., Wilhelm, O., Witthoft, M., & Koteles, F. (2021).
Psychological models of development of idiopathic environmental intolerances: Evidence from longitudinal population-based data. Environ Res, 204(Pt A), 111774. doi:10.1016/j.envres.2021.111774
https://www.ncbi.nlm.nih.gov/pubmed/34506786