Placebo Publications September 2021

Today we present 29 new placebo and nocebo research papers, comments and abstracts identified during Septermber 2021. As usual, they are based on new PUBMED publication using the search terms „placebo“ and „nocebo“ and are hand-selected from more than 825 new publications during the preceding month. Previously published monthly updates can be found in our archive. Todays selection as well as all previously identified papers will also go into our placebo research library that currently contains nearly 5,000 relevant papers. If you would like to get access to the full database, please register for our newsletter and provide us with your email address and affiliation.

Asan, L., Benson, S., & Bingel, U. (2021).
[Primum nil nocere: The nocebo effect in clinical practice]. MMW Fortschr Med, 163(15), 56-61. doi:10.1007/s15006-021-0173-4

Aslaksen, P. M. (2021).
Cutoff criteria for the placebo response: a cluster and machine learning analysis of placebo analgesia. Sci Rep, 11(1), 19205. doi:10.1038/s41598-021-98874-0

Atlas, L. Y. (2021).
A social affective neuroscience lens on placebo analgesia. Trends Cogn Sci. doi:10.1016/j.tics.2021.07.016

Barth, J., Muff, S., Kern, A., Zieger, A., Keiser, S., Zoller, M., Rosemann, T., Brinkhaus, B., Held, L., & Witt, C. M. (2021).
Effect of Briefing on Acupuncture Treatment Outcome Expectations, Pain, and Adverse Side Effects Among Patients With Chronic Low Back Pain: A Randomized Clinical Trial. JAMA Netw Open, 4(9), e2121418. doi:10.1001/jamanetworkopen.2021.21418

Beard, D. J., Campbell, M. K., Blazeby, J. M., Carr, A. J., Weijer, C., Cuthbertson, B. H., Buchbinder, R., Pinkney, T., Bishop, F. L., Pugh, J., Cousins, S., Harris, I., Lohmander, L. S., Blencowe, N., Gillies, K., Probst, P., Brennan, C., Cook, A., Farrar-Hockley, D., Savulescu, J., Huxtable, R., Rangan, A., Tracey, I., Brocklehurst, P., Ferreira, M. L., Nicholl, J., Reeves, B. C., Hamdy, F., Rowley, S. C., Lee, N., & Cook, J. A. (2021).
Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop. Health Technol Assess, 25(53), 1-52. doi:10.3310/hta25530

Borner, N., Weniger, M., Nossek, J., Kuonath, A., Schoenberg, M., Bosch, F., Angele, M., Frey, D., Werner, J., & Guba, M. (2021).
Patient expectations shape convalescence after major liver surgery – A prospective, randomized study. Int J Surg, 94, 106128. doi:10.1016/j.ijsu.2021.106128

Braithwaite, F. A., Walters, J. L., Moseley, G. L., Williams, M. T., & McEvoy, M. P. (2021).
A novel blinding protocol to test participant and therapist blinding during dry needling: a randomised controlled experiment. Physiotherapy. doi:10.1016/

Colloca, L., Thomas, S., Yin, M., Haycock, N. R., & Wang, Y. (2021).
Pain experience and mood disorders during the lockdown of the COVID-19 pandemic in the United States: an opportunistic study. Pain Rep, 6(3), e958. doi:10.1097/PR9.0000000000000958

Cusin, C., & Colloca, L. (2021).
Treatment-Resistant Depression-Resistant to Placebos as Well? JAMA Netw Open, 4(9), e2127952. doi:10.1001/jamanetworkopen.2021.27952

Howard, J. P., Wood, F. A., Finegold, J. A., Nowbar, A. N., Thompson, D. M., Arnold, A. D., Rajkumar, C. A., Connolly, S., Cegla, J., Stride, C., Sever, P., Norton, C., Thom, S. A. M., Shun-Shin, M. J., & Francis, D. P. (2021).
Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment. J Am Coll Cardiol, 78(12), 1210-1222. doi:10.1016/j.jacc.2021.07.022

Iolascon, G., & Moretti, A. (2021).
Myths and Truths about Placebo Effect in Rehabilitation for Musculoskeletal Pain. Adv Ther, 38(10), 4995-5001. doi:10.1007/s12325-021-01894-5

Jones, B. D. M., Razza, L. B., Weissman, C. R., Karbi, J., Vine, T., Mulsant, L. S., Blumberger, D. M., & Daskalakis, Z. J. (2021).
Magnitude of the Placebo Response Across Treatment Modalities Used for Treatment-Resistant Depression in Adults: A Systematic Review and Meta-analysis. JAMA Netw Open, 4(9), e2125531. doi:10.1001/jamanetworkopen.2021.25531

Kalokairinou, L., Specker Sullivan, L., & Wexler, A. (2021).
Neurofeedback as placebo: a case of unintentional deception? J Med Ethics. doi:10.1136/medethics-2021-107435

Leganes-Fonteneau, M., Bates, M. E., Islam, S., & Buckman, J. F. (2021).
Changes in interoception after alcohol administration correlate with expectancies and subjective effects. Addict Biol, e13098. doi:10.1111/adb.13098

Maher, C. G., Traeger, A. C., Abdel Shaheed, C., & O’Keeffe, M. (2021).
Placebos in clinical care: a suggestion beyond the evidence. Med J Aust. doi:10.5694/mja2.51230

Nann, S. (2021).
How beliefs in traditional healers impact on the use of allopathic medicine: In the case of indigenous snakebite in Eswatini. PLoS Negl Trop Dis, 15(9), e0009731. doi:10.1371/journal.pntd.0009731

Nasir, M., Li, F., Courley, S., Olten, B., & Bloch, M. H. (2021).
Meta-Analysis: Pediatric Placebo Response in Depression Trials Does Not Replicate in Anxiety and Obsessive-Compulsive Disorder Trials. J Child Adolesc Psychopharmacol. doi:10.1089/cap.2021.0030

Nayernouri, T. (2021).
The Expectant Brain and the Placebo Magic; Does it have a Survival Value? Arch Iran Med, 24(7), 585-590. doi:10.34172/aim.2021.83

Paumgartten, F. J. R. (2021).
Equipoise, placebo in clinical trials and Brazilian Code of Medical Ethics. Rev Assoc Med Bras (1992), 67(4), 490-495. doi:10.1590/1806-9282.20200929

Rakita, L., Goy, H., & Singh, G. (2021).
Descriptions of Hearing Aids Influence the Experience of Listening to Hearing Aids. Ear Hear. doi:10.1097/AUD.0000000000001130

Ruschil, V., Mazurak, N., Hofmann, M., Loskutova, E., Enck, P., Freilinger, T., & Weimer, K. (2021).
Decreased Autonomic Reactivity and Psychiatric Comorbidities in Neurological Patients With Medically Unexplained Sensory Symptoms: A Case-Control Study. Front Neurol, 12, 713391. doi:10.3389/fneur.2021.713391

Samartin-Veiga, N., Pidal-Miranda, M., Gonzalez-Villar, A. J., Bradley, C., Garcia-Larrea, L., O’Brien, A. T., & Carrillo-de-la-Pena, M. T. (2021).
Transcranial direct current stimulation of three cortical targets is no more effective than placebo as treatment for fibromyalgia: a double-blind sham-controlled clinical trial. Pain. doi:10.1097/j.pain.0000000000002493

Schaefer, M., Kuhnel, A., & Enge, S. (2021).
Comment on Evers et al. “What Should Clinicians Tell Patients about Placebo and Nocebo Effects?”: Open-Label Placebos May Reduce Feelings of Hunger during Weight Loss. Psychother Psychosom, 1-2. doi:10.1159/000518803

Shi, Y., Cui, S., Zeng, Y., Huang, S., Cai, G., Yang, J., & Wu, W. (2021).
Brain Network to Placebo and Nocebo Responses in Acute Experimental Lower Back Pain: A Multivariate Granger Causality Analysis of fMRI Data. Front Behav Neurosci, 15, 696577. doi:10.3389/fnbeh.2021.696577

Shi, Y., Zhan, H., Zeng, Y., Huang, S., Cai, G., Yang, J., & Wu, W. (2021).
Sex Differences in the Blood Oxygen Level-Dependent Signal to Placebo Analgesia and Nocebo Hyperalgesia in Experimental Pain: A Functional MRI Study. Front Behav Neurosci, 15, 657517. doi:10.3389/fnbeh.2021.657517

Torregrossa, M. M. (2021).
Failure of Losartan in a Clinical Trial for Posttraumatic Stress Disorder: Lack of Efficacy or Spotlight on the Power of Placebo? Biol Psychiatry, 90(7), 432-433. doi:10.1016/j.biopsych.2021.07.009

Toth, P. P. (2021).
That Myalgia of Yours Is Not From Statin Intolerance. J Am Coll Cardiol, 78(12), 1223-1226. doi:10.1016/j.jacc.2021.07.025

Vecchio, A., & De Pascalis, V. (2021).
ERP Indicators of Self-Pain and Other Pain Reductions due to Placebo Analgesia Responding: The Moderating Role of the Fight-Flight-Freeze System. Brain Sci, 11(9). doi:10.3390/brainsci11091192

Watrin, L., Nordin, S., Szemerszky, R., Wilhelm, O., Witthoft, M., & Koteles, F. (2021).
Psychological models of development of idiopathic environmental intolerances: Evidence from longitudinal population-based data. Environ Res, 204(Pt A), 111774. doi:10.1016/j.envres.2021.111774

Download PDF here.