Placebo Publications November 2021

Today we present 26 new placebo and nocebo research papers, comments and abstracts identified during November 2021. As usual, they are based on new PUBMED publication using the search terms „placebo“ and „nocebo“ and are hand-selected from more than 1038 new publications during the preceding month. Previously published monthly updates can be found in our archive. Todays selection as well as all previously identified papers will also go into our placebo research library that currently contains nearly 5,000 relevant papers. If you would like to get access to the full database, please register for our newsletter and provide us with your email address and affiliation.

Almradi, A., Sedano, R., Hogan, M., Zou, G. Y., MacDonald, J. K., Parker, C. E., Hanzel, J., Crowley, E., Singh, S., D’Haens, G., Sandborn, W. J., Feagan, B. G., Ma, C. & Jairath, V. (2021).
Clinical, endoscopic and safety placebo rates in induction and maintenance trials of Crohn’s disease: Meta-analysis of Randomised controlled trials. J Crohns Colitis. doi:10.1093/ecco-jcc/jjab194

Amanzio, M., Mitsikostas, D. D., Giovannelli, F., Bartoli, M., Cipriani, G. E., & Brown, W. A. (2022).
Adverse events of active and placebo groups in SARS-CoV-2 vaccine randomized trials: A systematic review. Lancet Reg Health Eur, 12, 100253. doi:10.1016/j.lanepe.2021.100253

Braga, M., Barbiani, D., Emadi Andani, M., Villa-Sanchez, B., Tinazzi, M., & Fiorio, M. (2021).
The Role of Expectation and Beliefs on the Effects of Non-Invasive Brain Stimulation. Brain Sci, 11(11). doi:10.3390/brainsci11111526

Cao, B., Liu, Y. S., Selvitella, A., Librenza-Garcia, D., Passos, I. C., Sawalha, J., Ballester, P., Chen, J., Dong, S., Wang, F., Kapczinski, F., Dursun, S. M., Li, X. M., Greiner, R. & Greenshaw, A. (2021).
Differential power of placebo across major psychiatric disorders: a preliminary meta-analysis and machine learning study. Sci Rep, 11(1), 21301. doi:10.1038/s41598-021-99534-z

Fragoulis, G. E., Bournia, V. K., Mavrea, E., Evangelatos, G., Fragiadaki, K., Karamanakos, A., Kravariti, E., Laskari, K., Panopoulos, S., Pappa, M., Mitsikostas, D. D., Tektonidou, M. G., Vassilopoulos, D. & Sfikakis, P. P. (2021).
COVID-19 vaccine safety and nocebo-prone associated hesitancy in patients with systemic rheumatic diseases: a cross-sectional study. Rheumatol Int. doi:10.1007/s00296-021-05039-3

Frisaldi, E., Shaibani, A., Trucco, M., Milano, E., & Benedetti, F. (2021).
What is the role of placebo in neurotherapeutics? Expert Rev Neurother, 1-11. doi:10.1080/14737175.2022.2012156

Geers, A. L., Clemens, K. S., Faasse, K., Colagiuri, B., Webster, R., Vase, L., Sieg, M., Jason, E., & Colloca, L. (2021).
Psychosocial Factors Predict COVID-19 Vaccine Side Effects. Psychotherapy and psychosomatics, 1–3. Advance online publication. doi: 10.1159/000519853

Glissen Brown, J. R., & Lembo, A. J. (2021).
Therapeutics, Placebo, and the Importance of Hard Outcomes in Irritable Bowel Syndrome Research. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2021.10.041

Grundy, S. M., & Vega, G. L. (2021).
Statin Intolerance and Noncompliance: An Empiric Approach. Am J Med. doi:10.1016/j.amjmed.2021.09.014

Hjorth, O. R., Frick, A., Gingnell, M., Hoppe, J. M., Faria, V., Hultberg, S., Alaie, I., Mansson, K. N. T., Rosen, J., Reis, M., Wahlstedt, K., Jonasson, M., Lubberink, M., Antoni, G., Fredrikson, M. & Furmark, T. (2021).
Expectancy effects on serotonin and dopamine transporters during SSRI treatment of social anxiety disorder: a randomized clinical trial. Transl Psychiatry, 11(1), 559. doi:10.1038/s41398-021-01682-3

Ho, J. T., Krummenacher, P., Lesur, M. R., Saetta, G., & Lenggenhager, B. (2021).
Real Bodies Not Required? Placebo Analgesia and Pain Perception in Immersive Virtual and Augmented Reality. J Pain. doi:10.1016/j.jpain.2021.10.009

Kanner, A. M., Patten, A., Ettinger, A. B., Helmstaedter, C., Meador, K. J., & Malhotra, M. (2021).
Does a psychiatric history play a role in the development of psychiatric adverse events to perampanel… and to placebo? Epilepsy Behav, 125, 108380. doi:10.1016/j.yebeh.2021.108380

Klinger, R., Solle, A., & Worm, M. (2021).
Response to “Targeted Use of Placebo Effects Decreases Experimental Itch in Atopic Dermatitis Patients: A Randomized Controlled Trial”. Clin Pharmacol Ther. doi:10.1002/cpt.2483

Liu, P., Zhang, X., & Zhou, R. (2021).
The Mindset of Intelligence Is Not a Contributor of Placebo Effects in Working Memory Training. Front Psychol, 12, 712309. doi:10.3389/fpsyg.2021.712309

Mun, C. J., Weaver, K. R., Hunt, C. A., Owens, M. A., Phillips, J., Lerman, S. F., Buenaver, L. F., Colloca, L., Tennen, H., Haythornthwaite, J. A., Finan, P. H. & Smith, M. T. (2021).
Pain Expectancy and Positive Affect Mediate the day-to-day Association Between Objectively Measured Sleep and Pain Severity Among Women With Temporomandibular Disorder. J Pain. doi:10.1016/j.jpain.2021.11.003

Prossin, A., Koch, A., Campbell, P., Laumet, G., Stohler, C. S., Dantzer, R., & Zubieta, J. K. (2021).
Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission. Mol Psychiatry. doi:10.1038/s41380-021-01365-x

Qiu, Y., Mao, Z., & Yun, D. (2021).
Can the add-on placebo effect augment the physical and mental health outcomes of exercise? A meta-analysis. Appl Psychol Health Well Being. doi:10.1111/aphw.12315

Schmidt, J., Reinold, J., Klinger, R., & Benson, S. (2021).
[Systemic inflammation, “sickness behavior” and expectations : What role do expectations play in inflammation-associated symptoms?]. Schmerz. doi:10.1007/s00482-021-00602-0

Schmitz, J. (2021).
[Placebo in pain therapy]. MMW Fortschr Med, 163(20), 62-66. doi:10.1007/s15006-021-0404-8

Schott, G. D. (2021).
Sacred images of the West and alleviation of pain: belief, placebo and harnessing hope. J R Soc Med, 114(12), 552-555. doi:10.1177/01410768211056315

Scott, A. J., Sharpe, L., Quinn, V., & Colagiuri, B. (2021).
Association of Single-Blind Placebo Run-in Periods With the Placebo Response in Randomized Clinical Trials of Antidepressants: A Systematic Review and Meta-analysis. JAMA Psychiatry. doi:10.1001/jamapsychiatry.2021.3204

Sezer, D., de Leeuw, M., Netzer, C., Dieterle, M., Meyer, A., Buergler, S., Locher, C., Ruppen, W., Gaab, J. & Schneider, T. (2021).
Open-Label Placebo Treatment for Acute Postoperative Pain (OLP-POP Study): Study Protocol of a Randomized Controlled Trial. Front Med (Lausanne), 8, 687398. doi:10.3389/fmed.2021.687398

Silva, B. M., da Silva, A. B. J., de Melo, F. L., & Ramos, R. E. M. (2021).
Targeted Use of Placebo Effects Decreases Experimental Itch in Atopic Dermatitis Patients: A Randomized Controlled Trial. Clin Pharmacol Ther. doi:10.1002/cpt.2481

Smith, L. E., Sim, J., Amlot, R., Cutts, M., Dasch, H., Sevdalis, N., Rubin, G. J. & Sherman, S. M. (2021).
Side-effect expectations from COVID-19 vaccination: Findings from a nationally representative cross-sectional survey (CoVAccS – wave 2). J Psychosom Res, 152, 110679. doi:10.1016/j.jpsychores.2021.110679

Sung, Y. K., & Lee, Y. H. (2021).
The lessebo effect in randomized controlled trials of rituximab in patients with rheumatoid arthritis: a meta-analysis. Z Rheumatol. doi:10.1007/s00393-021-01126-9

Wang, Y., Chan, E., Dorsey, S. G., Campbell, C. M., & Colloca, L. (2021).
Who are the placebo responders? A cross-sectional cohort study for psychological determinants. Pain. doi:10.1097/j.pain.0000000000002478

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